Document Type : Original Article
Authors
1
M.Sc in Perfusion Technology, Department of Extra-Corporeal Circulation (ECC), Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2
Associated Professor, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3
Associated Professor, Department of Anesthesiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4
Professor, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
5
M.Sc in Physiology, Department of Extra-Corporeal Circulation (ECC), Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
6
M.Sc in Medical-Surgical Nursing, Department of Extra-Corporeal Circulation (ECC), Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
7
B.Sc in Nursing, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
8
B.Sc in Nursing, Department of Critical Care, Razavi Hospital, Mashhad, Iran
9
M.Sc in Perfusion Technology, Department of Extra-Corporeal Circulation (ECC), Razavi Hospital, Mashhad, Iran
Abstract
Background: Cardiac protection strategies in different methods are challenging and crucial, affecting postoperative morbidity and mortality.
Objectives: We compared the cardio-protective effect of two cardioplegia solutions based on coronary sinus lactate levels.
Methods: This randomized, double-blinded clinical trial study was performed on 46 candidates for mitral valve replacement between June 2020 and January 2021. The patients were categorized via block randomization method: 1) St. Thomas I cardioplegia (n=23) and St. Thomas Ⅱ cardioplegia (n=23). The coronary sinus lactate levels at different times were measured. In addition, some intra-operative and clinical characteristics after cardiac surgery were recorded. Data were analyzed in SPSS software (version 26.0) using paired and independent t-tests, repeated measure ANOVA, and Pearson correlation test at a significance level of P < 0.05.
Results: In the time trend, the lactate levels in patients with St. Thomas Ⅱ cardioplegia solution had a significantly lower rate than in St. Thomas I (P=0.001). The two groups displayed no statistical difference between the aortic cross-clamp time (P=0.069) and the CPB time (P=0.091). Furthermore, the weaning from mechanical ventilation (P=0.078) and ICU stay (P=0.061) demonstrated no statistical difference between the study groups.
Conclusion: Based on significantly lower measures of the coronary sinus lactate, the St. Thomas Ⅱ cardioplegia solution showed a better cardio-protective effect in patients undergoing mitral valve surgery.
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