Echocardiographic evaluation of post MI patients with consistent ST segment elevation who underwent angiography: a follow up study

Document Type : Original Article

Authors

1 MD Resident of Cardiology, Department of Cardiology, Faculty of Medicineof Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 MD Cardiologist, associated professor of cardiology, Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Percutaneous intervention(PCI) is an accepted method of reperfusion in patients with acute ST-segment elevation myocardial infarction (STEMI). Establishing coronary blood flow during angiography does not always result in proper cardiac circulation. There are many factors related to patient outcomes after primary PCI. ST-segment resolution (STSR) is one of these factors that can be achieved noninvasively and indicates reperfusion. However, the relationship between STSR and echocardiographic findings is not widely studied. The aim of the present study is to evaluate electrocardiogram (ECG) and echocardiography findings in post-STEMI patients undergoing PCI.
 
Materials and methods: A total of 340 patients who had STEMI and underwent successful PCI were chosen by convenience sampling and enrolled in this follow up study. After considering the exclusion criteria, 12-lead ECG was performed on each patient at 60min, 90min, 120min, 24 h and 2 months after PCI. Additionally,a transthoracic echocardiogram (TTE) was performed after PCI, and 2 additional TTEs were performed—one each at 24 hpost-PCI and 2 months after PCI. ST-segment resolution was evaluated in every ECG, and the results were compared with the TTE findings.
 
Results: The mean±SD for the time duration between the onset of symptoms and calling EMS, the door-to-balloon time, and the time duration between the first medical staff visit andangioplasty were 114.4±56.63 min, 35.58±4.43 min and 60.58±4.43 min, respectively. Ejection fraction and end systolic volume in patients with ST-segment resolution greater than 30% at 60min, 90min, 120min and 24 h after PCI were significantly higher than that in patients with resolution lower than 30%. This finding was not observed 2 months after PCI.
 
Conclusion: While delays in managing patients with STEMI had favorable outcomes in our center in contrast to similar studies, attempts should be made to reduce these delays. STSR greater than 30% at 90min and 120min after successful PCI in patients with STEMI is significantly related with higher ejection fractions and lower end-systolic volumes. However, if the STSR occurs after 24 hours, then these patients are more likely to have lower ejection fractionsand larger end-systolic volumes.

Keywords


Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

1. Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, et al. Demographic and epidemiologic drivers of global cardiovascular mortality. New England Journal of Medicine. 2015;372(14):1333-41.
https://doi.org/10.1056/NEJMoa1406656
PMid:25830423 PMCid:PMC4482354
 
2. Ahmadi A, Soori H, Mehrabi Y, Etemad K, Samavat T, Khaledifar A. Incidence of acute myocardial infarction in Islamic Republic of Iran: a study using national registry data in 2012. East Mediterr Health J. 2014.
https://doi.org/10.26719/2015.21.1.5
PMid:25907187
 
3. Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. The Lancet.389(10065):197-210.
https://doi.org/10.1016/S0140-6736(16)30677-8
PMid:27502078
 
4. O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, De Lemos JA, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. Circulation. 2013;127(4):e362-e425.
 
5. Infusino F, Niccoli G, Fracassi F, Roberto M, Falcioni E, Lanza GA, et al. The central role of conventional 12-lead ECG for the assessment of microvascular obstruction after percutaneous myocardial revascularization. Journal of electrocardiology. 2014;47(1):45-51.
https://doi.org/10.1016/j.jelectrocard.2013.10.002
PMid:24290322
 
6. Shah A, Wagner GS, Granger CB, O'Connor CM, Green CL, Trollinger KM, et al. Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis: Reexamining the "gold standard" for myocardial reperfusion assessment. Journal of the American College of Cardiology. 2000;35(3):666-72.
https://doi.org/10.1016/S0735-1097(99)00601-4
PMid:10716469
 
7. Ito H, Maruyama A, Iwakura K, Takiuchi S, Masuyama T, Hori M, et al. Clinical implications of the 'no reflow'phenomenon. Circulation. 1996;93(2):223-8.
https://doi.org/10.1161/01.CIR.93.2.223
PMid:8548892
 
8. Claeys MJ, Bosmans J, Veenstra L, Jorens P, De Raedt H, Vrints CJ. Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction. Circulation. 1999;99(15):1972-7.
https://doi.org/10.1161/01.CIR.99.15.1972
PMid:10209000
 
9. de Lemos JA, Braunwald E. ST segment resolution as a tool for assessing the efficacy of reperfusion therapy. Journal of the American College of Cardiology. 2001;38(5):1283-94.
https://doi.org/10.1016/S0735-1097(01)01550-9
PMid:11691496
 
10. Hallén J, Sejersten M, Johanson P, Atar D, Clemmensen PM. Influence of ST-Segment Recovery on Infarct Size and Ejection Fraction in Patients With ST-Segment Elevation Myocardial Infarction Receiving Primary Percutaneous Coronary Intervention. The American Journal of Cardiology. 2010;105(9):1223-8.
https://doi.org/10.1016/j.amjcard.2009.12.034
PMid:20403470
 
11. Thiele H, Eitel I, Meinberg C, Desch S, Leuschner A, Pfeiffer D, et al. Randomized Comparison of Pre-Hospital-Initiated Facilitated Percutaneous Coronary Intervention Versus Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction Very Early After Symptom Onset: The LIPSIA-STEMI Trial (Leipzig Immediate Prehospital Facilitated Angioplasty in ST-Segment Myocardial Infarction). JACC: Cardiovascular Interventions. 2011;4(6):605-14.
https://doi.org/10.1016/j.jcin.2011.01.013
PMid:21700245
 
12. Kassaian SE, Masoudkabir F, Sezavar H, Mohammadi M, Pourmoghaddas A, Kojouri J, et al. Clinical characteristics, management and 1-year outcomes of patients with acute coronary syndrome in Iran: the Iranian Project for Assessment of Coronary Events 2 (IPACE2). BMJ open. 2015;5(12):e007786.
https://doi.org/10.1136/bmjopen-2015-007786
PMid:26671947 PMCid:PMC4679985
 
13. Farag EM, Al-Daydamony MM. Symptom-to-balloon time and myocardial blush grade are predictors of left ventricular remodelling after successful primary percutaneous coronary intervention. Cardiovascular journal of Africa. 2016;27:1-5.
 
14. Lenz CJ, Abdelmoneim SS, Anavekar NS, Foley TA, Nhola LF, Huang R, et al. A comparison of infarct mass by cardiac magnetic resonance and real time myocardial perfusion echocardiography as predictors of major adverse cardiac events following reperfusion for ST elevation myocardial infarction. Echocardiography (Mount Kisco, NY). 2016;33(10):1539-45.
https://doi.org/10.1111/echo.13308
PMid:27546353
 
15. Farkouh ME, Reiffel J, Dressler O, Nikolsky E, Parise H, Cristea E, et al. Relationship between ST-segment recovery and clinical outcomes after primary percutaneous coronary intervention: the HORIZONS-AMI ECG substudy report. Circulation Cardiovascular interventions. 2013;6(3):216-23.
https://doi.org/10.1161/CIRCINTERVENTIONS.112.000142
PMid:23652600
 
16. Sanati HR, Mahjoob MP, Zahedmehr A, Ghahferokhi FS, Firoozi A, Kiani R, et al. Risk Factors of Reperfusion Failure following Primary Angioplasty for ST-Segment Elevation Myocardial Infarction (STEMI). The Journal of Tehran University Heart Center. 2013;8(3):146-51.
 
17. Nijveldt R, van der Vleuten PA, Hirsch A, Beek AM, Tio RA, Tijssen JGP, et al. Early Electrocardiographic Findings and MR Imaging-Verified Microvascular Injury and Myocardial Infarct Size. JACC: Cardiovascular Imaging. 2009;2(10):1187-94.
https://doi.org/10.1016/j.jcmg.2009.06.008
PMid:19833308
 
18. 30. Somitsu Y, Nakamura M, Degawa T, Yamaguchi T. Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. The American journal of cardiology. 1997;80(4):406-10.
https://doi.org/10.1016/S0002-9149(97)00386-X
PMid:9285649
 
19. Kim J-S, Ko Y-G, Yoon S-J, Moon J-Y, Kim YJ, Choi BW, et al. Correlation of serial cardiac magnetic resonance imaging parameters with early resolution of ST-segment elevation after primary percutaneous coronary intervention. Circulation Journal. 2008;72(10):1621-6.
https://doi.org/10.1253/circj.CJ-08-0232
PMid:18756038