Ovarian Hyper Stimulation Syndrome in Two Spontaneous Pregnancies


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Khatamolanbia Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran

2 Women Health Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

3 Department of Infertility and IVF, Faculty of Medicine, Montaserieh Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

4 School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran


Introduction: Ovarian hyper stimulation syndrome (OHSS) occurs mainly after excessive stimulation of the ovaries by exogenous gonadotropin administered in the context of ovulation induction and in vitro fertilization procedures (iatrogenic OHSS). Spontaneous OHSS is a rare event. Such cases would explain other etiologies except ovulation induction. In this case report, we have presented two cases of OHSS in spontaneously conceived pregnancies. Case Presentation: In this case report, we are going to present two cases of OHSS occurring in spontaneously conceived pregnancies. One of the patients mentioned the history of this syndrome in her sister, and the other one confronted with this syndrome in her second pregnancy. Both of them referred to the hospital with typical symptoms and signs of OHSS. They did not have Polycystic Ovary Syndrome (PCOS) and any other problem in pregnancy. Thrombophilia workup, Tumor markers, renin-aldosterone and thyroid function tests were normal. Discussion: The presence of OHSS in spontaneous pregnancy especially in familial pattern may lead us to evaluate some endogenous pathogenic factors.


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