Document Type : Original Article
Authors
1 Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Extra-Corporeal Circulation (ECC), Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
3 Pediatric and Congenital Cardiology Division, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Cardiovascular disease, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Extra-Corporeal Circulation (ECC), Razavi Hospital, Imam Reza International University, Mashhad, Iran
Abstract
Keywords
Acknowledgements: The authors would like to express their gratitude to the cardiac surgery staff in Imam Reza Hospital, Razavi Hospital, and Shahid Rajaie Cardiovascular Medical and Research Institute for their invaluable cooperation and support throughout the study.
Availability of data and materials: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Conflicts of interests: The authors declare that they have none.
Consent for publication: Not applicable.
Ethics approval and consent to participate: The Mashhad University of Medical Sciences ethics committee approved the study protocol under IR.MUMS.MEDICAL.REC.1400.186, which complies with the Declaration of Helsinki. The study was registered under the IRCT registration number: IRCT20210710051837N1.
Financial disclosure: No financial support was received for this study.
Author contributions: Sh.A.: Contributed to the conception of the work, revising the draft, approving the final version of the manuscript, and agreeing on all aspects of the work; F. H.: contributed to the critical revision, and approval of the final version of the manuscript; M. R. N. S.: Contributed to the conception and design of the study, critical revision, and approval of the manuscript's final version; M.Y.: Contributed to the conception and design of the study, drafting of the manuscript and critical revision, and approval of final version.
Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/
| 1. Arki M, Moeinipour A, Fathi M, Abbasi Teshnizi M, Pasandi H, Heydari M, et al. The effects of St. Thomas I and St. Thomas II Cardioplegia solutions on coronary sinus lactate in mitral valve surgery; A Randomized, Double-blinded, Clinical Trial. Razavi Int J Med. 2023; 11(3): 12-16. | ||||
| 2. Ghasemi R, Vojdanparast M, Hosseinzadeh Maleki M, Yaghubi M. The Effect of the Door to Needle Time of Streptokinase Administration on the QTc Interval and the Incidence of Life-Threatening Arrhythmia in Patients With Anterior Myocardial Infarction. Acta Med Iran. 2022;60(3):144-149. https://doi.org/10.18502/acta.v60i3.9001 |
||||
| 3. Naghibi Sistani M, Alizadeh B, Birjandi H, Mottaghi Moghaddam Shahri H, Fatemi Z, et al. The Indispensable Role of Cardiac Catheterization Before Surgical Intervention of Pediatrics Undergoing Tetralogy of Fallot Total Correction; A Single Center Experience.Inn J Pediatr 2024;34(5):e147153. https://doi.org/10.5812/ijp-147153 |
||||
| 4. Namdar S, Zirak N, Naghibi Sistani M, Saffari Khozani E, Hosseinzadeh Maleki M, et al. The Effect of Normothermia and Moderate Hypothermia Cardiopulmonary Bypass on Early Clinical Outcomes in Low-Risk Pediatrics Undergoing Congenital Heart Defects Surgery. Inn J Pediatr. 2025; 35 (3): e159576. https://doi.org/10.5812/ijpediatr-159576 |
||||
| 5. Khosravi MB, Kahrom M, Tahari M, Alizadeh K, Soltani G, Ghanad MA. Effect of the Aortic Root Infusion of Sufentanil on Ischemia-Reperfusion Injury in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial. J Tehran Heart Cent. 2019 Oct;14(4):177-182. https://doi.org/10.18502/jthc.v14i4.2004 PMid:32461758 PMCid:PMC7231684 |
||||
| 6. Soltani G, Jahanbakhsh S, Tashnizi MA, Fathi M, Amini S, Zirak N, Sheybani S. Effects of Dexmedetomidine on heart arrhythmia prevention in off-pump coronary artery bypass surgery: A randomized clinical trial. Electron Physician. 2017 Oct 25;9(10):5578-5587. https://doi.org/10.19082/5578 PMid:29238500 PMCid:PMC5718864 |
||||
| 7. Liu X, Zhang K, Wang W, Xie G, Fang X. Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to Propofol: a randomized controlled trial. Critical Care. 2016;20(1):298. https://doi.org/10.1186/s13054-016-1480-5 PMid:27654700 PMCid:PMC5031329 |
||||
| 8. Cheng H, Li Z, Young N, Boyd D, Atkins Z, Ji F, et al. The effect of Dexmedetomidine on outcomes of cardiac surgery in elderly patients. Journal of cardiothoracic and vascular anesthesia. 2016;30(6):1502-8. https://doi.org/10.1053/j.jvca.2016.02.026 PMid:27435836 PMCid:PMC5010787 |
||||
| 9. Kleinbongard P, Heusch G. Extracellular signalling molecules in the ischaemic/reperfused heart - druggable and translatable for cardioprotection? Br J Pharmacol. 2015 Apr;172(8):2010-25. Epub 2014 Nov 24. PMID: 25204973; PMCID: PMC4386978. https://doi.org/10.1111/bph.12902 PMid:25204973 PMCid:PMC4386978 |
||||
| 10. Lempiäinen J, Finckenberg P, Mervaala EE, Storvik M, Kaivola J, Lindstedt K, Levijoki J, Mervaala EM. Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury. Pharmacol Res Perspect. 2014 Jun;2(3):e00045. Epub 2014 Apr 22. PMID: 25505591; PMCID: PMC4186414. https://doi.org/10.1002/prp2.45 PMid:25505591 PMCid:PMC4186414 |
||||
| 11. Elgebaly AS, Fathy SM, Sallam AA, Elbarbary Y. Cardioprotective effects of propofol-dexmedetomidine in open-heart surgery: A prospective double-blind study. Ann Card Anaesth. 2020 Apr-Jun;23(2):134-141. PMID: 32275025; PMCID: PMC7336971. https://doi.org/10.4103/aca.ACA_168_18 PMid:32275025 PMCid:PMC7336971 |
||||
| 12. Liang G, Li Y, Li S, Huang Z. Efficacy of Dexmedetomidine on myocardial ischemia/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2023 Mar 3;102(9):e33025.. PMID: 36862913; PMCID: PMid:36862913 PMCid:PMC9981381 https://doi.org/10.1097/MD.0000000000033025 PMid:36862913 PMCid:PMC9981381 |
||||
| 13. Bøtker HE, Cabrera-Fuentes HA, Ruiz-Meana M, Heusch G, Ovize M. Translational issues for mitoprotective agents as adjunct to reperfusion therapy in patients with ST-segment elevation myocardial infarction. J Cell Mol Med. 2020 Mar;24(5):2717-2729. Epub 2020 Jan 22. PMID: 31967733; https://doi.org/10.1111/jcmm.14953 PMid:31967733 PMCid:PMC7077531 |
||||
| 14. Wang L, Wang S, Xing Z, Li F, Teng J, Jia T. Application of Dexmedetomidine in Cardiopulmonary Bypass Prefilling. Dose Response. 2020 Jul 6;18(3):1559325820939764. https://doi.org/10.1177/1559325820939764 PMid:32669984 PMCid:PMC7338644 |
||||
| 15. Fathi M, Valaei M, Ghanbari A, Ghasemi R, Yaghubi M. Comparison of Patient's Kidney Function Based on Kidney Disease Improving Global Outcomes (KDIGO) Criteria and Clinical Parameters in Isolated Coronary Artery Bypass Graft (CABG) Surgery in On-Pump and Off-pump Methods in Patients with Low Cardiac Output Syndrome (LCOS) After Surgery. Anesth Pain Med. 2020 Apr 19;10(2):e100517. https://doi.org/10.5812/aapm.100517 PMid:32754433 PMCid:PMC7352649 |
||||
| 16. Ju Y, Xiao F, Lu J, Zhou B, Cai J, Chen S. Effect of Dexmedetomidine and cholinergic anti-inflammatory pathways in myocardial ischemia-reperfusion injury. Pak J Pharm Sci. 2020 May;33(3(Special)):1377-1382. | ||||
| 17. Fan J, Ma J, Xia N, Sun L, Li B, Liu H. Clinical Value of Combined Detection of CK-MB, MYO, cTnI and Plasma NT-proBNP in Diagnosis of Acute Myocardial Infarction. Clin Lab. 2017 Mar 1;63(3):427-433 https://doi.org/10.7754/Clin.Lab.2016.160533 |
||||
| 18. Gong Z, Ma L, Zhong YL, Li J, Lv J, Xie YB. Myocardial protective effects of Dexmedetomidine in patients undergoing cardiac surgery: A meta-analysis and systematic review. Exp Ther Med. 2017 May;13(5):2355-2361. https://doi.org/10.3892/etm.2017.4227 PMid:28565849 PMCid:PMC5443241 |
||||
| 19. Bulow NM, Colpo E, Pereira RP, Correa EF, Waczuk EP, Duarte MF, Rocha JB. Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass. Braz J Med Biol Res. 2016;49(4):e4646. https://doi.org/10.1590/1414-431X20154646 PMid:26909786 PMCid:PMC4792505 |
||||
| 20. Zuo Y, Cheng X, Gu E, Liu X, Zhang L, Cao Y. Effect of aortic root infusion of sufentanil on ischemia-reperfusion injury in patients undergoing mitral valve replacement. J Cardiothorac Vasc Anesth. 2014;28(6):1474-8. https://doi.org/10.1053/j.jvca.2014.04.023 PMid:25312265 |
||||
| 21. Ventura C, Spurgeon H, Lakatta EG, Guarnieri C, Capogrossi MC. Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons. Circ Res 1992; 70:66-81. https://doi.org/10.1161/01.RES.70.1.66 PMid:1309318 |
||||
| 22. Zhang X, Yan F, Feng J, Qian H, Cheng Z, Yang Q, Wu Y, Zhao Z, Li A, Xiao H. Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway. PLoS One. 2018 May 3;13(5):e0196897. https://doi.org/10.1371/journal.pone.0196897 PMid:29723264 PMCid:PMC5933780 |
||||
| 23. Chen M, Li X, Mu G. Myocardial protective and anti-inflammatory effects of Dexmedetomidine in patients undergoing cardiovascular surgery with cardiopulmonary bypass: a systematic review and meta-analysis. J Anesth. 2022 Feb;36(1):5-16. https://doi.org/10.1007/s00540-021-02982-0 PMid:34342722 PMCid:PMC8330189 |
||||
| 24. Ghasemi R, Imani Moghaddam S, Ramezani F, Yaghubi M. The Effect of the Door to Needle Time of Streptokinase Administration on the Left Ventricular Function and Thrombolysis in Myocardial Infarction (TIMI) Flow Grade in Patients With Anterior Myocardial Infarction: A Single-Center, Prospective Follow-up Study. Acta Med Iran. 2022;60(4):229-234. https://doi.org/10.18502/acta.v60i4.9267 |
||||
| 25. Wang G, Niu J, Li Z, Lv H, Cai H. The efficacy and safety of Dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. PLoS One. 2018 Sep 19;13(9):e0202620. https://doi.org/10.1371/journal.pone.0202620 PMid:30231052 PMCid:PMC6145508 |
||||