Investigating the Clinical Course of COVID-19 Patients and its Relationship with Vaccine Administration

Document Type : Original Article

Authors

1 Non-communicable Diseases Research Center, Departman of Anesthesia, Faculty of Paramedices, Sabzevar University of Medical Sciences, Sabzevar, Iran

2 Non-communicable Diseases Research Center, Department of Operating Room, Faculty of Paramedices, Sabzevar University of Medical Sciences, Sabzevar, Iran

3 Iranian Research Center on Healthy Aging, Department of Operating Room, Faculty of Paramedices, Sabzevar University of Medical Sciences, Sabzevar, Iran

4 Iranian Research Center on Healthy Aging, Prehospital medical emergencies Department, Faculty of Paramedics, Sabzevar University of Medical Sciences, Sabzevar, Iran

5 Non-Communicable Disease Research Center, Departman of Anesthesia, Faculty of Paramedices, Sabzevar University of Medical Sceinces, Sabzevar, Iran

6 Social Medicine Department, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

7 PhD Candidate in medical education, Department of Medical Education, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

8 Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran

9 Non-communicable Diseases Research Center, Operating Room Department, Faculty of Paramedices, Sabzevar University of Medical Sciences, Sabzevar, Iran

Abstract

Background: Assessing and monitoring the clinical progression of COVID-19 can provide valuable insights for developing effective treatment protocols and improving patient stability after discharge. This study aims to assess the clinical course of COVID-19 patients and their association with the administration of recommended vaccines.
 
Objectives: Investigating the clinical course of COVID-19 and its relationship with vaccine administration.
 
Methods: A cross-sectional study was conducted on 140 patients with COVID-19 who were discharged from Vasei Hospital, Sabzevar, Iran, between February and July 2022. Participants were selected via convenience sampling. A researcher-developed questionnaire was used to evaluate recovery progress at 4 and 12 weeks' post-discharge. Data were analyzed using SPSS v.24 with a significance level of 0.05.
 
Results: The administration of recommended vaccine doses showed a significant relationship with the recovery rate at the second follow-up (12 weeks, P = 0.026), but not at the first follow-up (4 weeks). A significant relationship was found between the PCR test result at the second period and the recovery rate at the first follow-up (P = 0.002), but not at the second follow-up (P = 0.51).
 
Conclusion: The study findings indicate that vaccination impacts both immunity levels and the long-term recovery of patients with COVID-19.

Keywords

Acknowledgements: We thank the research deputy of Sabzevar University of Medical Sciences for their financial support. We also extend our gratitude to all medical experts who participated in this study.

 

Availability of data and materials: Data is provided within the manuscript.

 

Conflicts of interests: The authors declare no competing interests.

 

Consent for publication: Not applicable.

 

Ethics approval and consent to participate: This study was approved by the Ethics Committee of Sabzevar University of Medical Sciences (IR.MEDSAB.REC.1400.136) and was assigned the project code 400124. All methods were performed in accordance with the relevant guidelines and regulations. Participants were selected via convenience sampling from Vasei Hospital, which served as the sole COVID-19 center in Sabzevar. Before data collection, the study's purpose was thoroughly explained to all potential participants. Informed written consent was obtained verbally via telephone, a procedure approved by the ethics committee, and all participant questions were addressed.

 

Financial disclosure: This study was supported by a grant from Sabzevar University of Medical Sciences.

 

Author contributions: Conceptualization; A D M GH, H Y, M KSH, and R Z; Data curation; F B, B K, E S, Formal analysis; Investigation; Software; E N; Roles/Writing - original draft; A D M GH, H Y, F B, R Z and E S, review & editing; A D M GH, H Y, F B.

 

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

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Razavi Journal of Medicine
Volume 14, Issue 1
January 2026
Pages 55-65

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