Role of MicroRNA in Mesenchymal Stem Cells Differentiation Into Osteblasts

Document Type : Review Article/ Systematic Review Article/ Meta Analysis

Authors

1 School of Biological Sciences, University of the Punjab, Quaid iAzam Campus, Lahore, Pakistan

2 Institute of Biochemistry and Biotechnology. University of the Punjab, Lahore, Pakistan

Abstract

Context: miRNAs can regulate the expression of genes by interfering in their mRNAs, acting as key regulators ol diverse cellular activities. Osteoblast differentiation is an important process for skeletal developments and involves several mechanisms regulated by miRNAs. The data forthis article was collected from recently published peer reviewed articlesonroleofmiRNAinosteoblastsgrowth and differentiation.

Evidence Acquisition: In this review, our understanding of bone remodeling has been highlighted along with the summarized role of different miRNA that regulate mesenchymal stem cell towards osteoblast differentiation for therapeutic purposes. Results: Treatments through miRNAs can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery.

Conclusions: Further work is needed to be done to make miRNA treatments available to large number of people suffering from various bone diseases

Keywords

Razavi International Journal of Medicine
Volume 1, Issue 1 - Serial Number 1
November 2013
Pages 5-10

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