Choroidal Metastasis from Breast Cancer in a Young Male Patient, Case Report

Document Type : Case Report/Series

Authors

MD, Eye research center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background: To report an uncommon case of choroidal metastasis caused by male breast cancer.
 
Case report: A 35-year-old gentleman presented with decreased visual acuity of left eye for about 6 months. The patient had a history of infiltrating breast carcinoma. The patient underwent a mastectomy, chemotherapy, and radiation therapy for the cancer four years ago. He was under oral medical therapy with tamoxifen. Ophthalmoscopic examination, B-scan ultrasonography, Fundus autofluorescence, Macular Optical Coherence Topography and other imaging were characteristics of metastatic choroidal tumor. Systemic investigations disclosed advanced metastatic disease. Radiotherapy is the preferred treatment for alleviating the symptoms. he received six cycles of systemic chemotherapy every three weeks with Cyclophosphamide, Methotrexate, and 5-fluorouracil. 6 months after treatment the patients BCVA increased to 4/10, and there was a reduction observed in the size of the choroidal metastasis.
 
Conclusion: In situations involving choroidal metastasis, it is important to consider the possibility of breast cancer as the primary cancer. We report this case to highlight this unusual source of choroidal metastasis, in males.
 

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

References

1. Hood CT, Budd GT, Zakov ZN, Singh AD. Male breast carcinoma metastatic to the choroid: report of 3 cases and review of the literature. Eur J Ophthalmol. 2011;21(4):459-67. doi: 10.5301/EJO.2010.6191. [PubMed: 21188683].
https://doi.org/10.5301/EJO.2010.6191
PMid:21188683
 
2. Lagha A, Ayadi M, Largueche L, Krimi S, Chraiet N, Allani B, et al. Choroidal metastasis from breast cancer in a male patient treated successfully with systemic chemotherapy. Int J Case Rep Images. 2012;3:6-10. doi: 10.5348/ijcri-2012-07-141-CR-2.
https://doi.org/10.5348/ijcri-2012-07-141-CR-2
 
3. Georgalas I, Paraskevopoulos T, Koutsandrea C, Kardara E, Malamos P, Ladas D, et al. Ophthalmic metastasis of breast cancer and ocular side effects from breast cancer treatment and management: mini review. BioMed Res Inter. 2015;2015. doi; 10.1155/2015/574086. [PubMed: 26078956].
https://doi.org/10.1155/2015/574086
PMid:26078956 PMCid:PMC4442260
 
4. Mathis T, Jardel P, Loria O, Delaunay B, Nguyen AM, Lanza F, et al. New concepts in the diagnosis and management of choroidal metastases. Prog Retin eye Res. 2019;68:144-76. doi: 10.1016/j.preteyeres.2018.09.003. [PubMed: 30240895].
https://doi.org/10.1016/j.preteyeres.2018.09.003
PMid:30240895
 
5. Konstantinidis L, Rospond-Kubiak I, Zeolite I, Heimann H, Groenewald C, Coupland SE, et al. Management of patients with uveal metastases at the Liverpool Ocular Oncology Centre. Br J Ophthalmol. 2014;98(1):92-8. doi: 10.1136/bjophthalmol-2013-303519. [PubMed: 24169654]
https://doi.org/10.1136/bjophthalmol-2013-303519
PMid:24169654
Razavi International Journal of Medicine
Volume 11, Issue 2
May 2023
Pages 46-48

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