Evaluation of Macular Vasculature in Patients with Schizophrenia Compared to Healthy Subjects

Document Type : Original Article

Authors

1 Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Eye Research Center, Mashhad University of medical Sciences, Mashhad, Iran

3 Retina Research Center, Mashhad University of medical Sciences, Mashhad, Iran

4 Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background: The present study aims to evaluate the macular thickness and vasculature changes with a readily accessible method of Optical Coherence Tomography Angiography (OCT-A) in patients with schizophrenia compared to healthy individuals.
 
Methods: The present cross-sectional study was conducted in 2019 at Ibn-e-Sina Psychiatric Educational Hospital of Mashhad. Twenty-Two cases of schizophrenia treated with risperidone and 22 age-matched healthy individuals participated in the study. The severity of the disease was assessed using the Positive And Negative Syndrome Scale (PANSS) test. All participants underwent complete ophthalmic examination and OCTA imaging.
 
Results: There was a statistically significant difference for fovea full-thickness (P=0.021) and parafovea full retinal thickness (P=0.029) between schizophrenic and healthy subjects. Fovea full retinal thickness, parafovea full retinal thickness, Fovea vessel density, and parafovea vessel density were significantly lower in markedly ill schizophrenia patients than the moderately ill subgroup (P=0.027, P=0.017, P=0.034, P=0.015).
 
Conclusion: In the present study, retinal neural and vascular tissues could be used as a research model in schizophrenia. Foveal and parafoveal thickness was significantly lower in patients with schizophrenia than that of healthy subjects, but it does not necessarily mean that there is a degenerative process in the pathogenesis of schizophrenia.
 

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

References

1. Kaplan BJ. Kaplan and sadock's synopsis of psychiatry. Behavioral sciences/clinical psychiatry. Tijdschrift voor Psychiatrie 2016;58(1):609.
 
2. Woods BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. American Journal of Psychiatry 1998;155(12):1661-1670.
https://doi.org/10.1176/ajp.155.12.1661
PMid:9842773
 
3. Gaebel W, Riesbeck M, Larach VW, Falkai P, Zielasek J. Trends in Schizophrenia diagnosis and treatment. Advances in Psychiatry: Springer; 2019. p 603-619.
https://doi.org/10.1007/978-3-319-70554-5_35
 
4. Sullivan PF. How good were candidate gene guesses in schizophrenia genetics? Biological Psychiatry 2017;82(10):696.
https://doi.org/10.1016/j.biopsych.2017.09.004
PMid:29031917 PMCid:PMC6950644
 
5. Heinz A, Borgwardt S, DeLisi LE. Neuroimaging of Neurotransmitter Alterations in Schizophrenia and Its Relevance for Negative Symptoms. Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders: Springer; 2019. p 157-169.
https://doi.org/10.1007/978-3-319-97307-4_3
 
6. Stahl SM. Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate. CNS Spectr 2018;23(3):187-191.
https://doi.org/10.1017/S1092852918001013
PMid:29954475
 
7. Gold MS, Blum K, Febo M, Baron D, Modestino EJ, Elman I, Badgaiyan RD. Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems. Front Biosci (Schol Ed) 2018;10:309-325.
https://doi.org/10.2741/s518
PMid:29293435
 
8. Riordan AJ, Schaler AW, Fried JB, Paine TA, Thornton JE. Estradiol and luteinizing hormone reverse memory loss in phencyclidine model of schizophrenia: Evidence for hippocampal GABA action. bioRxiv 2017:207159.
https://doi.org/10.1101/207159
 
9. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001;49(1-2):1-52.
https://doi.org/10.1016/S0920-9964(01)00163-3
PMid:11343862
 
10. 1Chu EM-Y, Kolappan M, Barnes TR, Joyce EM, Ron MA. A window into the brain: an in vivo study of the retina in schizophrenia using optical coherence tomography. Psychiatry Research: Neuroimaging 2012;203(1):89-94.
https://doi.org/10.1016/j.pscychresns.2011.08.011
PMid:22917503 PMCid:PMC4024658
 
11. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13(2):261-76.
https://doi.org/10.1093/schbul/13.2.261
PMid:3616518
 
12. Leucht S, Kane JM, Kissling W, Hamann J, Etschel E, Engel RR. What does the PANSS mean? Schizophr Res 2005;79(2-3):231-8.
https://doi.org/10.1016/j.schres.2005.04.008
PMid:15982856
 
13. Hart NJ, Koronyo Y, Black KL, Koronyo-Hamaoui M. Ocular indicators of Alzheimer's: exploring disease in the retina. Acta Neuropathol 2016;132(6):767-787.
https://doi.org/10.1007/s00401-016-1613-6
PMid:27645291 PMCid:PMC5106496
 
14. Lee JY, Ahn J, Oh S, Shin JY, Kim YK, Nam H, Jeon B. Retina thickness as a marker of neurodegeneration in prodromal lewy body disease. Mov Disord 2020;35(2):349-354.
https://doi.org/10.1002/mds.27914
PMid:31710400
 
15. Ascaso FJ, Laura C, Quintanilla MÁ, Gutiérrez Galve L, López-Antón R, Cristóbal JA, Lobo A. Retinal nerve fiber layer thickness measured by optical coherence tomography in patients with schizophrenia: a short report. The European journal of psychiatry 2010;24(4):227-235.
https://doi.org/10.4321/S0213-61632010000400005
 
16. Lee WW, Tajunisah I, Sharmilla K, Peyman M, Subrayan V. Retinal nerve fiber layer structure abnormalities in schizophrenia and its relationship to disease state: evidence from optical coherence tomography. Invest Ophthalmol Vis Sci 2013;54(12):7785-92.
https://doi.org/10.1167/iovs.13-12534
PMid:24135757
 
17. Mota M, Pego P, Klut C, Pires G, Maia T. Retina and Schizophrenia. J Eye Cataract Surg 2017;3:21.
https://doi.org/10.21767/2471-8300.100025
 
18. Yilmaz U, Kucuk E, Ulgen A, Ozkose A, Demircan S, Ulusoy DM, Zararsiz G. Retinal nerve fiber layer and macular thickness measurement in patients with schizophrenia. Eur J Ophthalmol 2016;26(4):375-8
https://doi.org/10.5301/ejo.5000723
PMid:26742871
Razavi International Journal of Medicine
Volume 10, Issue 2
April 2022
Pages 23-27

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