Evaluation of Efficacy and Potential Complications of the Plant-Based Nanoparticles Hemostat Powder on Controlling Hemorrhage in Rat Models of Liver Injury: An Experimental Study

Document Type : Original Article

Authors

1 Associate professor of cardiac surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 General Physician, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

3 Assistant professor, Department of cardiac surgery, Faculty of medical science. Mashhad University of Medical Sciences, Iran

4 Researcher in education and research department of Razavi Hospital .Mashhad. Iran

5 Resident of cardiac surgery, Department of cardiac surgery, Faculty of medical science, Mashhad University of Medical Sciences, Iran

Abstract

Background: Liver resection requires time management due to the high risk of bleeding. Plant-based materials are superior to other agents in reducing complications during hemostasis. This present study aimed to investigate the effect of plant-based topical hemostatic nanoparticles from the rosaceous as an innovative hemostatic agent.
 
Methods: Twenty male Wistar rats were randomly divided into two study groups. All rats were anesthetized and their anterior lobe of the liver was amputated. The incision site was directly pressed with a dry gauze for 2 minutes in the control group and repeated every 30 seconds until hemostasis was achieved. Homeostatic material was compressed on the incision site and clotting time was recorded in the intervention group. The mean hemostasis time was compared in both groups using Paired Samples Test. P <0.05 was considered statistically significant.
 
Results: Hemostasis was successfully achieved in both groups. The hemostasis time were 6.7±1.33 and 183±26.26 in Nanoparticles and control groups, respectively and their differences were significant (P<0.001). Histopathology evaluation indicated a slight increase in vascularity, fibrosis, and polymorphonuclear neutrophil (PMN) infiltration in one case. Mild to moderate lymphocyte infiltration was detected in 2 cases.
 
Conclusion: The produced plant-based Nanoparticles could significantly reduce the hemostasis time in the intervention group compared to that of the control one.

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

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Razavi International Journal of Medicine
Volume 9, Issue 4
October 2021
Pages 6-10

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