Seropositivity of Antibodies Against Hepatitis A Virus in Mashhad, Northeast of Iran, 2009: A Cross-Sectional Community-Based Study

Document Type : Original Article

Authors

Research Center for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, IR Iran

Abstract

Background: Hepatitis A Virus (HAV) is the most common cause of acute viral hepatitis worldwide, mostly in developing countries.
 
Objectives: This population-based survey was performed to investigate HAV seroprevalence in Mashhad, northeast of Iran.
 
Patients and Methods: A cross-sectional study was performed on 1563 randomly selected individuals from general population of Mashhad, Iran, between May and September 2009. Serum samples were tested for total anti-HAV antibodies using the Enzyme-Linked Immunosorbent Assay (ELISA) kit. Data was analyzed using SPSS ver. 18.0 by Chi-square and Student’s t-Tests.
 
Results: Seroprevalence of HAV infection was 69.6% (95% CI: 67.3-71.9%) with no difference between males and females. Anti-HAV seropositivity increased with rising age from 9.4% in subjects younger than 5 years to 100.0% in individuals older than 65 years old (P < 0.001).
 
Conclusions: As it was previously reported by the World Health Organization (WHO) on HAV infection in the country, this study revealed a high prevalence of HAV infection in Mashhad.

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

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