Imatinib in Patients with Aggressive Fibromatosis and Pigmented Villonodular Synovitis: A Systematic Review

Arefpour, Amir Mohammad; Izanloo, Azra; Hajialiloo Sami, Sam; Mirkazemi, Masoud; Jamshidi, Khodamorad

doi:10.30483/rijm.2021.254210.1057

Imatinib in Patients with Aggressive Fibromatosis and Pigmented Villonodular Synovitis: A Systematic Review

Document Type : Original Article

Authors

¹ Firrozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

² Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran

³ Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran

⁴ Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, IR Iran

10.30483/rijm.2021.254210.1057

Abstract

Introduction: We undertook a systematic review of the literature to determine the efficacy and safety of Imatinib in the restriction of activity and effective treatment of patients with aggressive fibromatosis (AF) and pigmented villonodular synovitis (PVNS) and their recurrence.

Method: We searched studies in the PubMed and Cochrane collaborative library at all levels from 2010 to April 2019. Two independent reviewers evaluated the articles according to the predefined criteria and extracted the related data. Primary outcomes associated with tumor size shrinkage, relapse and overall survival along with secondary outcomes such as pain, quality of life, and side effects were investigated.

Results: 112 studies were evaluated out of which only 6 studies that covered original studies and case reports were entered into this systematic review. A total of 79subjects had participated in these six studies with an age range of 22 to 41 years old. In five studies, participants had a primary tumor and in one research they reported relapse. The
recommended dose was 400 mg/day, which was usually continued for 4 to 12 months.The tumor size shrinkage and low side effects of drugs have been reported.

Conclusion: According to the results, no systemic treatment for PVNS and AF has been approved so far, but many studies have demonstrated the efficacy of Imatinib in the treatment of these diseases. However, further studies are required for optimal treatment and combined therapies.

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

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Imatinib in Patients with Aggressive Fibromatosis and Pigmented Villonodular Synovitis: A Systematic Review

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Volume 9, Issue 2
April 2021
Pages 1-5

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Imatinib in Patients with Aggressive Fibromatosis and Pigmented Villonodular Synovitis: A Systematic Review

References

Volume 9, Issue 2April 2021Pages 1-5

Files

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How to cite

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Volume 9, Issue 2
April 2021
Pages 1-5