Lymphoma Masquerading as Tuberculosis of the Vertebra: Case Report and Discussion of Diagnosis

Authors

1 Department of Pathology, Iran University of Medical Sciences, Tehran, Iran

2 Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran

3 Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran

Abstract

Introduction: Mycobacterium tuberculosis is the cause of tuberculosis (TB), a serious pathogen in many parts of the world. According to the World Health Organization (WHO), one-third of the world's populations suffer from TB. Since Iran is an endemic region for TB, many practitioners have focused their attention on this issue.

Case Presentation: This study presents a patient who was misdiagnosed with TB due to the clinical symptoms of the disease and received the related treatment. But, the results of re-biopsy and immunohistochemistry tests approved the presence of Hodgkin's lymphoma in the patient.

Conclusion: In this case, the emphasis is on the differential diagnosis of Hodgkin's lymphoma of the spine and other masses. The possibility of an inflammatory process should always be considered alongside rare disorders such as lymphoproliferative to reduce the chance of putting the patient at the risk of disease progression and improper treatment course.

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

References

1.Zumla A, George A, Sharma V, Herbert RH, Oxley A, Oliver M. The WHO 2014 global tuberculosis report--further to go. Lancet Global Health. 2015;3(1):e10-2. [PubMed: 25539957].
https://doi.org/10.1016/S2214-109X(14)70361-4
PMid:25539957
 
2. Zumla A, Raviglione M, Hafner R, von Reyn CF. Tuberculosis. N Engl J Med. 2013;368(8):745-55. doi: 10.1056/NEJMra1200894. [PubMed: 23425167].
https://doi.org/10.1056/NEJMra1200894
PMid:23425167
 
3. Alan Selçuk N, Fenercioğlu A, Selçuk H, Uluçay C, Yencilek E. Multifoci bone tuberculosis and lymphadenitis in mediastinum mimics malignancy on FDG-PET/CT: a case report. Mol Imaging and Radionucl Ther. 2014;23(1):39-42 [PubMed: 24653936].
https://doi.org/10.4274/Mirt.145
PMid:24653936 PMCid:PMC3957972
 
4. Truszczyńska A, Nowak-Misiak M, Rąpała K, Walczak P. Tuberculosis of the spine masquerading as a spine lymphoma. A case report and discussion of diagnostic and therapeutic traps. Neurol Neurochirur Pol. 2013;47(2):189-93. [PubMed: 23650010].
https://doi.org/10.5114/ninp.2013.33823
PMid:23650010
 
5. Cagˇavi F, Kalayci M, Tekin I, Numanoğlu G, Cağavi Z, Gül S, et al. Primary spinal extranodal Hodgkin's disease at two levels. Clin Neurol Neurosurg. 2006;108(2):168-73. [PubMed: 16412837].
https://doi.org/10.1016/j.clineuro.2004.11.023
PMid:16412837
 
6. Stoller DW, Tirman PF, Bredella MA. Pocketradiologistmusculoskeletal: top 100 diagnoses. New York: W.B. Saunders Company; 2001. P. 200-2.
 
7. Castillo M, Midyett FA. Pocket radiologist: spine-top 100 diagnoses. Acad Radiol. 2002;9(12):1437-8.
https://doi.org/10.1016/S1076-6332(03)80675-X
https://doi.org/10.1016/S1076-6332(03)80676-1
 
8. Sandher DS, Al-Jibury M, Paton RW, Ormerod LP. Bone and joint tuberculosis. Cases in Blackburn between 1988 and 2005. J Bone Joint Surg Br. 2007;89(10):1379-81. [PubMed: 17957082].
https://doi.org/10.1302/0301-620X.89B10.18943
PMid:17957082
 
9. Langley CR, Garrett SJ, Urand J, Kohler J, Clarke NM. Primary multifocal osseous Hodgkin's lymphoma. World J Surg Oncol. 2008;6:34-9. [PubMed:18346271].
https://doi.org/10.1186/1477-7819-6-34
PMid:18346271 PMCid:PMC2311296
 
10. Citow JS, Rini B, Wollmann R, Macdonald RL. Isolated primary extranodal Hodgkin's disease of the spine: case report. Neurosurgery. 2001;49:453-6. [PubMed: 11504124].
https://doi.org/10.1227/00006123-200108000-00037
PMid:11504124
Razavi International Journal of Medicine
Volume 6, Issue 3
July 2018
Pages 17-20

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