Study of hs-CRP Level in Prisoners in Mashhad and Their Relation to Demographic Factors


1 Medical Ethics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mashhad, Iran. Tel: +985138002388; Email:

2 Department of Research and Education, Razavi Hospital, Mashhad, IR Iran

3 MD, specialist in Community Medicine, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4 PHD, Immunology Research Center, Inflammation and Inflammatory Diseases division, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

5 MSC, Immunology Research Center, Inflammation and Inflammatory Diseases division, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran


Abstract Background: Prisoners are a certain part of the population. Prisoners are kept in a closed environment for a long period of time and are prone to various diseases. Inflammatory biomarkers, including hs-CRP, are new risk factors for cardiovascular disease. Objectives: The aim of this study was to compare hs-CRP levels in male and female prisoners and investigate the relationship between hs-CRP levels with related factors. Methods: In this cross-sectional study, 316 prisoners in Mashhad Prison were investigated. A blood sample (7ml) was taken from each subject. Enzyme-linked immunosorbent assay (ELISA) technique was used to measure serum levels of highsensitivity C-reactive protein (hs-CRP). Descriptive statistics, chi-squared test, T-test, Pearson and Spearman’s correlation coefficients were used. P


  1. 1.Javadi A, Pourahmad M, Ataee B. Relation of frequency and duration of imprisonment with hepatitis B, C and HIV in prisoners. J Med Council Islam Repub Iran. 2006;385:64.

    1. Rosen DL, Hammond WP, Wohl DA, Golin CE. Disease prevalence and use of health care among a national sample of black and white male state prisoners. J Health Care Poor Underserved. 2012;23(1):254-72. doi: 10.1353/hpu.2012. 0033. [PubMed: 22643475].
    2. Iftene A, Manson A. Recent crime legislation and the challenge for prison health care. CMAJ. 2013;185(10):886-9. doi: 10.1503/cmaj.120222. [PubMed: 23128279].
    3. Manesh MJ, Soleimanifar P, Hosseini F. Personal, familial, social and economical characteristis of jailed addicted women. Iran J Nurs. 2005;17(40):47-54.
    4. Jalilian F, Alavi J. Prevalence and pattern of drug abuse among prisoners in Kermanshah city. Health Educ Promot. 2013;1(2):41-8.
    5. Mann DL, Zipes DP, Libby P, Bonow RO. Braunwald's heart disease: a textbook of cardiovascular medicine. New York: Elsevier Health Sciences; 2014.
    6. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet. 1997;349(9063):1436-42. doi: 10.1016/S0140- 6736(96)07495-8. [PubMed: 9164317].
    7. Kazemy T, Sharifzadeh G. Ten-year changes in mortality and risk factors in acute myocardial infarction in Birjand (1994- 2003). Horizon Med Sci. 2004;10(3):38-42.
    8. McBride JD, Cooper MA. A high sensitivity assay for the inflammatory marker C-Reactive protein employing acoustic biosensing. J Nanobiotechnol. 2008;6(1):5. doi: 10.1186/1477- 3155-6-5. [PubMed: 18445267].
    9. Henderson DJ. Drug abuse and incarcerated women: a research review. J Subst Abuse Treat. 1998;15(6):579-87. [PubMed: 9845871].
    10. O’Donovan A, Neylan TC, Metzler T, Cohen BE. Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study. Brain Behav Immun. 2012;26(4):642-9. doi: 10.1016/j.bbi. 2012.02.003. [PubMed: 22366689].
    11. Kauffman RM, Ferketich AK, Murray DM, Bellair PE, Wewers ME. Tobacco use by male prisoners under an indoor smoking ban. Nicotine Tob Res. 2011;13(6):449-56. doi: 10.1093/ntr/ntr024. [PubMed: 21447838].
    12. Fazel S, Bains P, Doll H. Substance abuse and dependence in prisoners: a systematic review. Addiction. 2006;101(2): 181-91. doi: 10.1111/j.1360-0443.2006.01316.x. [PubMed: 16445547].
    13. Asgari S, Amini F, Naderi G, Roozbahani R. Relationship between opium addiction and cardiovascular risk factors. J Birjand Univ Med Sci. 2008;15(1):40-4.
    14. Reece AS. High-sensitivity CRP in opiate addiction: relative and age-dependent elevations. Cardiovasc Toxicol. 2012;12(2):149- 57. doi: 10.1007/s12012-012-9154-2. [PubMed: 22297435].
    15. Bazzano LA, He J, Muntner P, Vupputuri S, Whelton PK. Relationship between cigarette smoking and novel risk factors for cardiovascular disease in the United States. Ann Intern Med. 2003;138(11):891-7. [PubMed: 12779299].
    16. Ghazavi A, Solhi H, Moazzeni SM, Rafiei M, Mosayebi G. Cytokine profiles in long-term smokers of opium (Taryak). J Addict Med. 2013;7(3):200-3. doi: 10.1097/ADM. 0b013e31828baede. [PubMed: 23519052].
    17. Ghazavi A, Mosayebi G, Solhi H, Rafiei M, Moazzeni SM. Serum markers of inflammation and oxidative stress in chronic opium (Taryak) smokers. Immunol Lett. 2013;153(1):22-6. doi: 10.1016/j.imlet.2013.07.001. [PubMed: 23850638].
    18. Ridker PM, Libby P. Risk factors for atherothrombotic disease. A textbook of cardiovascular medicine. 7th ed. Philadelphia: Elsevier Saunders; 2005. P. 939-58.
    19. Fröhlich M, Sund M, Löwel H, Imhof A, Hoffmeister A, Koenig W. Independent association of various smoking characteristics with markers of systemic inflammation in men. Eur Heart J. 2003;24(14):1365-72. [PubMed: 12871694].
    20. Tracy RP, Psaty BM, Macy E, Bovill EG, Cushman M, Cornell ES, et al. Lifetime smoking exposure affects the association of Creactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler Thromb Vasc Biol. 1997;17(10):2167-76. [PubMed: 9351386].
    21. Bautista LE, Lopez-Jaramillo P, Vera LM, Casas JP, Otero AP, Guaracao AI. Is C-reactive protein an independent risk factor for essential hypertension? J Hypertens. 2001;19(5):857-61. [PubMed: 11393667].
    22. Kim KI, Lee JH, Chang HJ, Cho YS ,Youn TJ, Chung WY, et al. Association between blood pressure variability and inflammatory marker in hypertensive patients. Circ J. 2008;72(2):293-8. [PubMed: 18219169].
    23. Rawson ES, Freedson PS, Osganian SK, Matthews CE, Reed G, Ockene IS. Body mass index, but not physical activity, is associated with C-reactive protein. Med Sci Sports Exerc. 2003;35(7):1160-6. doi: 10.1249/01.MSS.0000074565. 79230.AB. [PubMed: 12840637].