Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Department of Otolaryngology, Resident of Otolaryngology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Department of Otolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Students’ Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Abstract Background: Chronic rhinosinusitis (CRS) is the inﬂammation of paranasal sinusmucousmembranes. Considering the inﬂuence of fungi on chronic rhinosinusitis and diﬀerent results concerning the eﬀect of Amphotericin B on improvement of this condition; this study aimed to determine the eﬀect of topical Amphotericin B on improvement of the symptoms in patients with CRS. Methods: In this double-blind randomized clinical trial, 80 patients with chronic rhinosinusitis who visited the allergy clinic of BaqiyatallahHospital fromJune toOctober 2014were randomly allocated to two groups; the ﬁrst group received 10 cc topical lavage of Amphotericin B (5 cc each nostril for every 12 hours) and the second group received placebo for threemonths. Symptoms, nasal mucusa smear, serumlevel of inﬂammatory cytokines, CT scan and rhinoscopy score changes were evaluated in both groups after threemonths. Results: Fifty-ﬁve male and 25 female patients were evaluated in two groups. The mean age was 26.1 2.36 and 27.9 1.59 years in intervention and control groups respectively (P = 0.08). There were no signiﬁcant diﬀerences in demographic data between the groups (P > 0.05). Nasal obstruction, post nasal drip (PND), reduced sense of smell, quality of life, CT scan and rhinoscopy scores were not signiﬁcantly diﬀerent between the two groups after intervention (P > 0.05). Facial pain severity score was signiﬁcantly more reduced in intervention group in comparison with control group (P < 0.01). Conclusions: We concluded that application of Amphotericin B as an adjunctive medication to other common treatments, does not seemto be an eﬃcientmethod for improvement of CRS symptoms.