SerumPro-Oxidant-Antioxidant Balance, Advanced Oxidized Protein Products (AOPP) and Protein Carbonyl in PatientsWith Stroke

Toloue Pouya, Vajiheh; Issac Hashemy, Seyed; Shoeibi, Ali; Nosrati Tirkani, Abolfazl; Tavallaie, Shima; Zahedi Avval, Farnaz; Soukhtanloo, Mohammad; Ali Mashkani, Barat; Hamidi Alamdari, Daryoush

doi:10.30483/rijm.2016.116395

SerumPro-Oxidant-Antioxidant Balance, Advanced Oxidized Protein Products (AOPP) and Protein Carbonyl in PatientsWith Stroke

Authors

¹ Department of Biochemistry, Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad, IR Iran

² Surgical Oncology Research Center, ImamReza Hospital, Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad, IR Iran

³ Department of Neurology, GhaemHospital,Mashhad University of Medical Sciences,Mashhad, IR Iran

⁴ Biochemistry of Nutrition Research Center,Mashhad University of Medical Sciences,Mashhad, IR Iran

⁵ Department of Biochemistry, Biochemistry and Nutrition Research Center, Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad, IR Iran

10.30483/rijm.2016.116395

Abstract

Background: Stroke is the second cause of death and disability in the world, and oxidative stress which could be considered as a prognostic factor in patients for prevention, follow up and determination of stroke’s severity has a conceivable role in neural damage.

Objectives: The aim of our study was to explain the association between oxidant/antioxidant imbalance as a prognostic factor in patients with stroke.

Methods: Pro-oxidant-antioxidant balance (PAB), advanced oxidized protein products (AOPP) and protein carbonyl were measured in patients with ischemic stroke and hemorrhagic stroke as well as healthy group. Sera were collected from 18 is- chemic and 23 hemorrhagic stroke patients, and 34 healthy volunteers. The PAB assay, routine biochemical parameters, lipid proﬁle and total protein concentration were assessed in patients and healthy group.

Results: The level of AOPP (P < 0.007), protein carbonyl (P < 0.001) and PAB (P < 0.01) were signiﬁcantly higher in stroke patients than the healthy group.

Conclusions: There are increased level of protein carbonyl, AOPP and PAB in patients with stroke. Measuring these factors may be beneﬁcial as prognostic factors in treatment and follow up of the patients with both hemorrhagic and ischemic strokes. More investigations withmore cases and longer follow up are needed to approve that these factors play an important role in prognosis of stroke.

Keywords

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

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SerumPro-Oxidant-Antioxidant Balance, Advanced Oxidized Protein Products (AOPP) and Protein Carbonyl in PatientsWith Stroke

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Volume 4, Issue 2
April 2016
Pages 21-26

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SerumPro-Oxidant-Antioxidant Balance, Advanced Oxidized Protein Products (AOPP) and Protein Carbonyl in PatientsWith Stroke

References

Volume 4, Issue 2April 2016Pages 21-26

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Volume 4, Issue 2
April 2016
Pages 21-26