Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, IR Iran
Orthopedic Research Center,Mashhad University of Medical Sciences,Mashhad, IR Iran
Department of Research and Education, Razavi Hospital, Mashhad, IR Iran
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran
Abstract Background: Amajor purpose of treating open fractures is the prevention of wound infection. Infection, as amajor complication associated with open fractures,may lead to limb loss, sepsis, and even death. In this study, we survey factors aﬀecting infection. Objectives: In this study, we survey factors aﬀecting infection. Patients and Methods: The study population consisted of all patients with type IIIA gastilo open fractures of tibial shaft, with or without ﬁbula fracture (caused by trauma). Afterwound irrigation, debridement, andwound swab sampling formicrobial culture, all patients received prophylactic antibiotic regimens in ﬁtting with their wound class. No topical antibiotics were used with a 6-month follow-up for any symptomof osteomyelitis. Results: Considering the occurrence of one case of infection, the infection ratewas calculated (1.89%). Given the lowprevalence rate of infection, itwas diﬃcult to evaluate the eﬀect of diﬀerent antibiotic regimens on the prevention of infection (in terms of regimen duration). As such, no speciﬁc regimen was preferred. The results of statistical analysis did not show any signiﬁcant diﬀerence between one-day application of antibiotic prophylaxis and two or three days consumption of antibiotic prophylaxis. Conclusions: According to the results of this study, one-day administration of antibiotics as prophylaxis (ﬁrst generation of cephalosporins) was suﬃcient for the prevention of infection after orthopedic surgery in all patients except in patient with risk factors such as diabetes or immune deﬁciency, when the administration of prophylactic antibiotic lasts for 3 days.