Razavi Journal of Medicine

Razavi Journal of Medicine

Amniotic Fluid-Derived Stem Cells (AFSC) and Their Application in Cell Therapy and Tissue Engineering

Document Type : Review Article/ Systematic Review Article/ Meta Analysis

Authors
Syeda Zahra Anum 1
Seyed Raheel Muzavir 2
Ahmad Hassan 3
Amir Ali Khan 1, 4
Aftab Ahmad 2
1 Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
2 National Academy of Young Scientists, School of Biological Sciences, University of the Punjab, Lahore, Pakistan
3 Department of Biology, University of Veterinary and Animal Sciences, Lahore, Pakistan
4 Department of Neurosciences, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia
10.30483/rijm.2015.118375
Abstract
Context: Amniotic Fluid Derived Stem Cells (AFSC) has mesenchymal origin and is multipotent. Having played their role in the detection of genetic abnormalities in the unborn children, they are gaining attention in the regenerative medicine because of their pluripotency.
 
Evidence Acquisition: AFSCs possess great proliferating ability and have no ethical and religious issues in their use. AFSCs may also be studied for the stem cells differentiation such as production of multiple lineages of different cells like heart, liver, pancreas, etc. The potential of their use in regenerative medicine as well as their differentiation into multiple cells is possible.
 
Results: AFSCs have the potential to be used in tissue repair and regeneration of bladder and kidney injuries, for the treatment of congenital anomalies like tracheal anomalies and spina bifida therapy etc. However, like every therapeutic potential, AFSCs also have some limitations such as low rate of differentiation of transplanted AFSCs and immune rejection.
 
Conclusions: AFSCs have great therapeutic potential, but extensive research is warranted to overcome the limitations to use AFSC as therapy.
Keywords
Regenerative medicine
Amniotic Fluid
stem cells
Graft Rejection

Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

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Razavi Journal of Medicine
Volume 3, Issue 1
Winter 2015