Ocular Manifestations of Metabolic Syndrome


1 Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran

2 Department of Ophthalmology, Mashhad University of Medical Sciences, Mashhad, IR Iran

3 Student Research Committee, Department of Modern Sciences and New Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran

4 4Refractive Errors Research Center, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, IR Iran 5 Department of Optometry, Faculty of Paramedical Sciences, Mashhad University of Medical Sciences, Mash



Context: Metabolic syndrome (metabolic syndrome X) is a prevalent cluster of risk factors that include high BMI, hypertension, insulin resistance and dyslipidemia. Individuals with metabolic syndrome are at an increased risk of coronary artery disease (CAD) and diabetes mellitus. Diabetes mellitus and hypertension (HTN) are associated with retinopathy and cataract. Evidence Acquisition: Bibliographical searches were performed using MEDLINE/ScienceDirect/OVID up to October 2013 using the following keywords (all fields): (“metabolic syndrome” OR “Met syndrome”) AND [(ocular disease) OR (cataract) OR (glaucoma) OR (age- related maculopathy). Results: This review explores the relationship between metabolic syndrome, including all its components, and various ocular conditions such as retinopathy, central retinal artery occlusion, cataract and elevated intraocular pressure. Conclusions: Today, the prevalence of metabolic syndrome is increasing, because world population life in prevalence behaviors have changed. Its association with various ocular manifestations such as non-diabetic retinopathy, CRAO, cataract, and primary open angle glaucoma suggests that an epidemic of Met syndrome can have far-fetched ocular consequences as well.


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