Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 Razavi International Journal of Medicine, Pioneering the Path to Knowledge 1 2 118517 10.30483/rijm.2013.118517 EN Kamran GhafFarzadehgan Research and education department, Razavi hospital, Mashhad, IR Iran. Hami Ashra Research and education department, Razavi hospital, Mashhad, IR Iran Journal Article 2013 11 10 Razavi Hospital -a non-governmental hospital has focused on education and research activities besides to its health improving services in order to achieve the policies highly regarded by . Therefore, the hospital decided to establish an International Journal of Medicine with the aim of publishing highly qualified and scientific articles in accordance with recent scientific achievements. Razavi Hospital intends to pave the way for publish ing the scientific findings and achievements in medical field through establishing Razavi International Journal of Medicine. All scientists and scientific societies associated in various branches of medicine are invited to collaborate us in providing a friendly environment inorder to improve scientific interactions and develop human knowledge.

https://journal.razavihospital.ir/article_118517_756c89b237906c7f0460729e85a35f62.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 Personalized Cancer Medicine: a Future Direction of Personal Genomics 3 4 118518 10.30483/rijm.2013.254526.1326 EN Ehsan Ghayoor Karimiani department of New Sciences and Technology, Mashhad University of Medical Sciences, Mashhad, IR Iran Journal Article 2013 09 26 Personalized medicine is significantly changing the fundamentals of healthcare. Genetic diagnostic tests are used in various parts of medicine from initial screening to the diagnosis and finallytreatment. Investigations in fields of drug development indicate that oncology may lead other therapeutic areas in the number of targeted therapies on the marketplace as well as in the pipeline, expecting that within a few years, all oncology medications will have a related diagnosis. It has been shown that personal genomics will influence other important therapeutic areas, including the clinical decision making. In conclusion, personalized medicine is just getting started for hematology and respiratory medical therapies, as well as oncology.

https://journal.razavihospital.ir/article_118518_f88b5979a8d19732673df1d0651f50d2.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 Role of MicroRNA in Mesenchymal Stem Cells Differentiation Into Osteblasts 5 10 118519 10.30483/rijm.2013.118510 EN Aamina Shah Institute of Biochemistry and Biotechnology. University of the Punjab, Lahore, Pakistan Aftab Ahmad School of Biological Sciences, University of the Punjab, Quaid iAzam Campus, Lahore, Pakistan Journal Article 2013 09 16 Context: miRNAs can regulate the expression of genes by interfering in their mRNAs, acting as key regulators ol diverse cellular activities. Osteoblast differentiation is an important process for skeletal developments and involves several mechanisms regulated by miRNAs. The data forthis article was collected from recently published peer reviewed articlesonroleofmiRNAinosteoblastsgrowth and differentiation. Evidence Acquisition: In this review, our understanding of bone remodeling has been highlighted along with the summarized role of different miRNA that regulate mesenchymal stem cell towards osteoblast differentiation for therapeutic purposes. Results: Treatments through miRNAs can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. Conclusions: Further work is needed to be done to make miRNA treatments available to large number of people suffering from various bone diseases

https://journal.razavihospital.ir/article_118519_d4a30294fd42f7ea322208aecbaddc22.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 Electronic Health Records Acceptance and Implementation in Developing countries: Challenges and Barriers 11 16 118515 10.30483/rijm.2013.118518 EN Mohammad Reza Hassibian Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran Journal Article 2013 10 06 Context: This literature review mostly emphasizes on the challenges and barriers for acceptance and implementation of electronic health records (EHRs) in developing countries. Although the willingness of developing countries for acceptance and implementation of EHRs is rising, they will face some challenges and barriers which can slow down their progress due to the multidisciplinary and complexity characteristics of EHRs. Some of these challenges and barriers can be seen in the past and present histories of EHRs acceptance process in developed countries too. Familiarity with these challenges and barriers will help developing countries to have better understanding of these problems towards successful EHRs. The main goal of this survey is to study the challenges and barriers of acceptance and implementation of EHRs in the developing countries and how they can overcome such problems. Evidence Acquisition: Two databases, Pub-Med and Scopus with Combination of terms such as Electronic Health Records, Developing Countries, Barriers, Challenges, Acceptance, and Adoption were searched. Totally, 514 articles extracted. Some exclusive criteria such as date of publication (year 2000 and above) and having a close relation to the subject of the study (through abstract) were applied. The result was eight articles from Scopus and 12 articles from Pub-Med. Also, 7 articles were extracted by general search in internet. Also, 11 articles with the same search policies were selected from Journal of Health informatics for Developing Countries (JHIDC) with no exclusion criteria. Results: Developing countries must be fully aware of challenges and barriers in their way towards EHRs. They also need to study the experiences of countries which are successful in acceptance and implementation of EHRs. Developing countries also need to provide infrastructures needed for a successful implementation of EHRs. Conclusions: Despite the positive effects of EHRs in healthcare services, the acceptance rate of EHRs in developing countries and even developed countries is still low. The developing countries are facing many problems in their way toward implementing successful EHRs. Lack of infrastructures in information and communication technology, cost, and cultural resistance are considered as main barriers for developing countries in their approach to accept and implement EHRs.

https://journal.razavihospital.ir/article_118515_32588d33dba613333d986cf5385cee59.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 Diagnostic and Therapeutic Role of Long Term Video -EEG Monitoring in Patients with Psychogenic Non-Epileptic Attacks 17 21 118520 10.30483/rijm.2013.118544 EN Mohsen Aghaee Hakak Epilepsy Monitoring Unit, Research and Education Department, Razavi Hospital, Mashhad, IR Iran Hossein Amir Epilepsy Monitoring Unit, Research and Education Department, Razavi Hospital, Mashhad, IR Iran Malihe Mohammadpour Epilepsy Monitoring Unit, Research and Education Department, Razavi Hospital, Mashhad, IR Iran Iraj Vosough Epilepsy Monitoring Unit, Research and Education Department, Razavi Hospital, Mashhad, IR Iran Behnaz Razavi Epilepsy Monitoring Unit, Research and Education Department, Razavi Hospital, Mashhad, IR Iran Hami Ashraf Research and Education Department, Razavi Hospital, Mashhad, Iran Ali Gorji Epilepsy Research Center, Munster University, Munster, Germany shela Neuroscience Research Center, Tehran, Iran Journal Article 2013 08 31 Background: PNEA is a neuropsychiatric disorder which has lots of economical and psychological burden not only on patients and their families, but also on society and health systems. Long Term video-EEG Monitoring (LTM) is gold standard way in diagnosis of PNEA. Objectives: The aim of this study is to investigate occurrence of PNEA in patients admitted to the Razavi epilepsy department and role of LTM in definite diagnosis of PNEA. Materials and Methods: This study was retrospectively performed and the required information was gathered from database of admitted patients in epilepsy department of Razavi Hospital in 2011. All the patients with final diagnosis of PNEA were included in the study. They were all contacted with telephone thereafter to evaluate their clinical status and compare it with their condition before the clear diagnosis. Results: The results of this study revealed that, 24-hour LTM associated with noninvasive suggestive provocative techniques in patients with presumptive psychogenic events can lead to definite diagnosis of psychogenic non-epileptic attacks (PNEA). Conclusions: Definite diagnosis of PNEA not only reduces significantly unnecessary use of AEDs (P = 0.001) and psychotropic drugs, but also increases patients' productivity and emotional wellbeing. In addition, it leads them to accept diagnosis and iollow appropriate treatment.

https://journal.razavihospital.ir/article_118520_4facf87061211c9f17fa2f58968f44bb.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 Bayesian Analysis of Breast Cancer Mortality to Reduce the Effects of Misclassification 22 25 118521 10.30483/rijm.2013.118531 EN MohamadAmin Pourhoseingholi Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohsen Vahedi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Asma Pourhoseingholi Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sara Ashtari Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Journal Article 2013 09 10 Background: Breast cancer (BC) is the most common cancer in Iranian women. Studying the mortality statistics is important to monitor the effects of screening programs or the influence of earlier diagnosis on the burden of this chronic disease. Misclassification is still a problem in the Iranian death registry data and about 20% of death statistics are recorded in misclassified categories. Objectives: The aim of this study is to re-estimate the mortality rate of Breast cancer in the Iran by a Bayesian model in order to exclude the bias due to misclassification. Materials and Methods: The mortality data were extracted from national death Statistic, which reported or published by the Ministry of Health and Medical Education, from 1995 to 2004. The rate of mortality due to BC [1CD-10; C50] were expressed as the annual rates per/100,000 population in age group (< 15,15 - 49 and > 50 years of age) and also, age standardized rate (ASR) calculated in this study. To correct the misclassification effect, a Bayesian approach was used with Poisson count regression and beta prior. Results: The results of the Bayesian analysis indicated that there were between 20 to 30 percent misclassified deaths statistic in mortality records which did not reported and re-estimated by this model for BC. Also the rate of BC mortality has increased in recentyears; however it seems that the rate would be leveled off from 2002 to 2004. Conclusions: The findings revealed a substantial misclassified mortality statistics of BC in the Iranian women. Therefore policy makers in health scope should notice to this unreported data.

https://journal.razavihospital.ir/article_118521_0b65b1763162e05726a612f24b7ad762.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 01 Comparison Between Closed (Immediate Spica, Traction/Spica) and Open Fixation (Plate Fixation) in Femoral Shaft Fractures in Children Below Nine years Old Who Had Recoursed to Mashhad Imam Reza Hospital From 2002 to 2007 26 29 118522 10.30483/rijm.2013.118526 EN Hassan Rahimi Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran Mohammad Gharehdaghi Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran Ali Birjandinejad Research and Education Department, Razavi Hospital, Mashhad, IR Iran Masoud Mirkazem Research and Education Department, Razavi Hospital, Mashhad, IR Iran Hamidreza Azim Dental Research Center, Faculty of Dentistry, Mashhad Univercity of Medical Sciences, Mashhad, IR Iran Journal Article 2023 10 29 Background: Femur fracture is one of the most common fractures in children. Certain parameters such as the patient ’s age, the exact location of fracture, type of fracture, the mechanism of fracture, and the accompanying injuries determine which one of the many treatment techniques be used in each case. Objectives: We aimed to compare the results of close and open techniques in pediatric femoral shaft fractures fixation (under 9 years old). Patients and Methods: In this study, the clinical and radiologic results of the femur shaft fracture cases in children below 9 years old who recoursed to Mashhad Imam Reza Hospital. Twenty six cases of femoral shaft fractures in 25 children (14 boys and 11 girls) which could be classified in three different classes; nine upper third (proximal) femoral shaft fractures, 14 middle third (midshaft) femoral fractures, three lower third (distal) femoral shaft fractures. Thirteen fractures (50%) were treated with immediate Spica cast, six fractures (23%) received traction and Spica cast, and surgical fixation with plate was carried out in the remaining seven cases. Results: After a follow-up interval of at least 5 years, angle deformity was the most common complication observed in 32% of the studied patients. Limb length discrepancy and rotational deformity were observed in 24% and 16% of the cases. Treated with immediate Spica cast proved to have the highest complication prevalence of all (92.2%) and was followed by traction and Spica cast (83.4%) and were observed in patients'' surgical fixation with plate (14.3%). Conclusion: According to the results, internal fixation with plates can be considered an appropriate technique in cases of pediatric femoral shaft fractures.

https://journal.razavihospital.ir/article_118522_304bac21eb39b894dfe4645b01a2e4ee.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 01 Poor Breastfeeding as a Probable Cause of Childhood Malnutrition: Exploring Mothers' and Caregivers Views on Breastfeeding Via a Qualitative Study in Damavand, Iran 30 34 118516 10.30483/rijm.2013.118519 EN Maryam Amini Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Nahid Salarkia Department of Food and Nutrition Programming and Policy Making Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Babak Eshrati Department of Epidemiology, Arak University of Medical Sciences, Arak, IR Iran Abolghassem Djazayery Department of Community Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IR Iran Journal Article 2023 10 28 Background: Childhood malnutrition still persists in some parts of Iran. Poor breast feeding is proposed as a probable risk factor for malnutrition. Objectives: In the present study views, experiences and practices of mothers and caregivers about exclusive breast feeding was explored by a qualitative study in Damavand, Iran, a country with a relatively high prevalence of pediatric malnutrition. Materials and Methods: Urban and rural mothers who had under-2-year babies attended 11 FGDs. In addition, six FGDs were arranged for caregivers in urban and rural areas. All FGD notes were analyzed and emerging themes were derived and reported. Results: The findings indicated that although mothers were aware of breastfeeding benefits and regarded it as their responsibility, in few cases, neonates were fed by items other than breast milk. Exclusive breast feeding was not followed precisely. Pregnancy of mothers, lack of knowledge, misinformation and physician instruction were among the reasons why mother may stop breast- feeding. Mothers' and caregivers were aware of the importance of breast feeding in sick children. Conclusions: Mothers’ knowledge of exclusive breast feeding were satisfactory but their practice was not based on recommendations. As physicians play a role in this matter, the need for specific educational modules for them and other health staff is recommended. Meanwhile, parental education and everyone involved in childcare is a priority so that the problem can be overcome.

https://journal.razavihospital.ir/article_118516_e0e72952184c136d771bacc4ada0a371.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 01 Surgical Treatment of partial Agenesis of the left Pericardium 35 37 118523 10.30483/rijm.2013.11516 EN Tiago CesarMierzwa Assisi Gurgacz Faculty, Parana, Brazil RodrigoOtavio Gama Franca Ultrasonography Department, Cardiologist Medianeira Polyclinic Hospital, Parana, Brazil Rui Manuel Sequeira Almeida Assis Gurgacz Medical School, Parana, Brazil Journal Article 2013 09 04 Introduction: The pericardial agenesis is a rare congenital anomaly. Classified as partial or total being asymptomatic in most cases, but some patients are at risk for serious complicat ions and death, and these have indication for surgical treatment. Case Presentation: This paper describes the case of a 21 year old patient, with atypical precordial pain, diagnosed with agenesis ot the left pericardium confirmed by cardiac magnetic resonance imaging (MRI), in which a surgical correction was performed, by means of a neopericardium with bovine pericardial patch. Discussion: Follow-up in immediate post-operative period showed that the patient had no complications and clinical improvement, and after 15 months, a new MRI showed a normal cardiac image.

https://journal.razavihospital.ir/article_118523_aca76f98b87ae35fe646b51a0ebeddd3.pdf

Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 1 1 2013 11 15 The Second Razavi International Proctology Congress 38 41 118524 10.30483/rijm.2013.118525 EN Afshin Heydari Prociology Clinic, Razavi Hospital, Mashad, Iran Pier Paolo Dalmonte Department of Surgery, Gynepro Medical Bologna, Bologna, Italy Reza Fazlalizadeh Department of Surgery, Nuovo Ospedale Civile S. Agostino-Estense, Modena, Italy Aeed Hashemzadeh Prociology Clinic, Razavi Hospital, Mashad, Iran Aldo Infantine Sanvito General surgery Department, Sanvito al Tagliamento Hospital, Sanvito al tagliamento, Italy Filippo La Torre Colorectal and Pelvic Surgery Emergency Department, Policlinic of Umberto 1st College of Medicine, Sapienza University of Rome, Rome, Italy Piercarlo Meinero Proctology Unit, E. Riboli Hospital, Genoa, Italy Journal Article 2013 11 03 Purpose: Razavi hospital plays an important role in the field of medical research and tries to provide a good opportunityfor the researches and pioneers in different medical fields to share their knowledge. Considering the incidence and prevalence of colorectal diseases especially in Iran, these congresses may lead tofind the new solution. Summary of Presented Findings: The rapid evolution of technology over the last decade has led to the development of new instruments, diag nostic appliances and synthetic or natural materials for tissue repair. The terms "quality of life" and "quality of care", are now familiar in proctology. This has radically changed the rules of this sub-specialty. Now the proctologist must have a familiarity with this technological cornucopia and the use of high-tech materials as well in or der to pursue a correct diagnosis and a proper treatment of the diseasesHence a continuous updating in this field is needed to the state of the art. Recommendation : Colorectal diseases such as Fistula, Haemorrhoid and Incontinence are common and because of the refractory cases, especially in the case of Fistula, we have to find the efficient treaments. It needs more time and more researches should be done.

https://journal.razavihospital.ir/article_118524_1b68701d9f3edfdc0135e0cd3f236f07.pdf