Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 10 2 2022 06 01 Primary malignant melanoma of bone (clear cell sarcoma): A case report 103 107 118470 10.30483/rijm.2022.254411.1233 EN Vahideh Moein Department of Orthopedic, Faculty of Medicine, Islamic Azad University, Tehran, Iran Azra Izanloo Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran Mohammad Jalili Department of Pathology, Erfan Nyayesh Hospital, Tehran, Iran Mohammad Vaezi Hematology and Oncology and Stem Cell Transplantation Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Masoud Mirkazemi Department of Orthopedic, Faculty of Medicine, Islamic Azad University, Tehran, Iran Journal Article 2021 04 15 Melanoma is a malignant tumor that predominantly arises in the skin. In rare cases, however, it can manifest in the bone too. In this paper, a primary malignant melanoma of the lesser trochanter of the right femur is described.<br />In this case, the subject was a 19-year-old woman presenting with pelvic floor pain that lasted for 3 weeks.<br />Magnetic resonance imaging (MRI) showed that T2MRI has bone melanoma soft tissue edema that sustained to malignant melanoma.<br />Immunohistochemistry report revealed that tumoral cells were positive for HMB45, S100, which is suggestive of melanoma diagnosis.<br />The patient was admitted and underwent CNB. Since the result was negative, the patient received a wide local excision from the right lesser trochanter. <br />The histopathological examination of biopsy revealed fibro sclerotic tissue affected by malignant melanoma.<br />The patient was then referred to an oncologist for postoperative adjust chemotherapy and target therapy. https://journal.razavihospital.ir/article_118470_8d454dfd9cd63371cad5fdd410d78531.pdf