Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 7 2 2019 03 30 Association between Intake and Serum Selenium Levels and Risk Factors of Cardiovascular Disease (Narrative Review) 1 7 118314 10.30483/rijm.2019.118314 EN Naseh Pahlavani Students Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Daryoush Rostami Department of Anesthesia, School of Paramedical Sciences, Zabol University of Medical Sciences, Zabol, Iran Majid Rezaei Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Gordon Ferns Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK Majid Ghayour-mobarhan Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran Journal Article 2018 04 06 <strong>Background:</strong> Selenium (Se) is an essential trace element and is a potent antioxidant that is involved in the activity of several enzymes such as glutathione peroxidase (GPx). Selenium metabolism is associated with the biology of heart and its functions, and selenium deficiency is associated with cardiovascular pathology. Several studies indicate a relationship between selenium and cardiovascular disease.<br /> <br /><strong>Objectives: </strong>The aim of this study was the investigation of the role of selenium in cardiovascular disease.<br /> <br /><strong>Methods: </strong>We searched the ISI, PubMed, Scopus, and Google Scholar databases for studies that evaluated the association between selenium levels and cardiovascular health and cardiovascular disease. At first, the studies containing the words "selenium ", "cardiovascular disease", "selenium supplementation", "levels of selenium" and "hypertension" were selected. We searched papers using ‘selenium_, ‘selenium supplementation_, ‘selenium deficiency_and, ‘Se_in combination with ‘cardiovascular disease_, ‘hypertension_’, ‘heart disease_’, ‘heart failure_’ as keywords.<br /> <br /><strong>Results: </strong>17 articles (6 randomized clinical trials and 11 observational studies) were eligible to be included in the current review. Some clinical trials have shown that selenium supplementation could reduce the risk of cardiovascular disease including lipid profiles and inflammatory markers. Observational studies showed that low selenium concentrations are a risk factor of cardiovascular disease however, this is not definitive. But the presence of normal levels of selenium is essential for antioxidant defense.<br /> <br /><strong>Conclusion: </strong>More clinical trial studies with larger sample size are needed to confirm that selenium is effective in preventing and treatment of cardiovascular disease. https://journal.razavihospital.ir/article_118314_2f5d34c720cb3e1bb7909c7fb7d81b05.pdf