Mashhad Razavi Hospital Razavi Journal of Medicine 3115-753X 4 3 2016 07 01 Clinical and Histopathology Features of Spitz Nevus: In 22 Cases 1 5 113505 10.30483/rijm.2016.117390 EN Mahtab Rahbar Associated Professor, Iran University of Medical Sciences, Tehran, IR Iran Ali Ghannadan Associated Professor, Tehran University of Medical Sciences, Tehran, IR Iran Kambiz Kamyab Associated Professor, Tehran University of Medical Sciences, Tehran, IR Iran Journal Article <strong> Background</strong>: Spitz Nevus is an infrequent acquired melanocytic nevus. There is still a challenge for dermatopathologists in dis- tinguishing spitz nevus from malignant melanoma particularly in adults since there is no immunohistochemistry or molecular markers which differentiate Spitz Nevus frommelanoma.<br /><strong>Objectives</strong>: The aim of this study is to make clear what clinico-histopathological features of Spitz Nevus are in order to reduce malpractice due tomisdiagnosis.<br /> <br /><strong>Methods:</strong> In the present study, a series of twenty two patients have been reviewed who were diagnosed with Spitz Nevous based on proved histopathology features between the years 2009 - 2013. The patients were evaluated for demographic parameters like age, sex, clinical differential diagnosis, cutaneous location of tumor, tumor diameter, subtype, symmetry,maturation, upper cleft- ing of melanocytic nest, shoulder phenomena, epidermal hyperplasia, type, kamino body,mitotic rate , inflammatory infiltration, pagetoid spread and regression.<br /> <br /><strong> Results</strong>: In our study, 45% of patientswere younger than 10 years old. The average age of patientswas 1411.37. Male to female ratio was 1.44. The commonest location was head and neck. Spitz nevus was the first clinical differential diagnosis in 20% of patients. The commonest variant type was conventional type and then polypoid and desmoplastic types. The mean size of nevi was 0.81  0.59mm. About 59% of nevi shows epithelioid cytologic features. Other histologic parameters fromthemost to the least frequency were symmetry (100%), maturation (100%), epidermal hyperplasia (77.3%), kamino body (68.2%), subtype (compound 68%), mitotic rate (63.6%), clefting (59%), inflammatory infiltration (54.5%), pagetoid spread (18.2%), shoulder (37.5%) and regression (9.1%).<br /> <br /><strong>Conclusions</strong>: We tried to hifhlight some clinical and histopathological features which are distinguishing Spitz nevus from other melanocytic nevi evenmalignantmelanoma. https://journal.razavihospital.ir/article_113505_7c0c44081119837b62e4ea508c6f00ba.pdf