Effect of Glucose-Insulin-Potassium infusion on systolic and diastolic functions in patients with chronic ischemic cardiomyopathy

Document Type : Original Article


1 Saman Heart Clinic, Mashhad, Iran

2 Cardiology department, Mehr Hospital, Mashhad, Iran

3 Chemical and Biomolecular Department ,UCLA,USA



Background:Ischemic cardiomyopathy is accompanied with some degrees of decreased metabolism.So,a method to facilitate cellular absorption and use of glucose may promote myocardial function and viability .Glucose,Potassium.Insulin solution(GIK) has been used by some successful results in acute ischemic heart disease and decreases the extent of ischemic zone in myocardium and promote ventricular function.
Method and Materials: 25 patients with ischemic cardiomyopathy(EF<40%)with stable clinical condition who referred to emergency department or clinic of cardiology were enrolled in our study.They were assessed by echocardiographic indexes before and after GIK administration to evaluate the effects of GIK on systolic and diastolic function of the heart in chronic ischemic cardiomyopathy.
Results: Male to female ratio was 4:1 in our study. According to echocardiographic findings, left heart end diastolic indexes didn't show any significant statistical changes (p>0.005) but diastolic function of left ventricle were improved significantly after administration of GIK (p <0.005) .Despite there wasn't outstanding change on improvement of systolic left and right ventricular function (p>0.005), but because of metabolic improvements and increased in ventricular function after GIK administration, clinical symptoms were decreased.
Conclusion:GIK solution administration(As an accessible and cost-effective agent) may improve ventricular diastolic function and clinical symptoms,so we suggest GIK as an effective therapeutic method in ischemic cardiomyopathy.