Gastroenterology and Hepatology Research Center,Mashhad University of Medical Sciences,Mashhad, Iran
Assistant Professor, Gastroenterology and Hepatology,Mashhad University of Medical Sciences,Mashhad, Iran
Assistant Professor, Gastroenterology and Hepatology, Sabzevar University of Medical Sciences, Sabzevar, Iran
Assistant Professor of Microbiology, Sabzevar University of Medical Sciences, Sabzevar, Iran
Associate Professor, Gastroenterology and Hepatology,Mashhad University of Medical Sciences,Mashhad, Iran
Assistant Professor, Gastroenterology, Department of InternalMedicine,Mashhad Branch, Islamic Azad University,Mashhad, I
Abstract Background: Inﬂammatory bowel disease is a disorder with unknown origin in which environment, genetics, and immunity play a part. Although colonoscopy and biopsy are expensive and invasive, are used to monitoring the mucosal inﬂammation. Fecal calprotectin is a non-invasive test which has attracted a lot of attention. We aimed to determine the relation of fecal calprotectin and clinical activity of ulcerative colitis. Methods: This cross-sectional study took place with the conﬁrmation of ethics committee of Mashhad University of Medical Sci- ences in 2014 - 2015. Patients with diagnosis of ulcerative colitis were included; demographic information was recorded and clinical activity of disease was evaluated. Fecal calprotectin was measured by the quantitative ELISA method and results of laboratory studies and clinical examinations were analyzed by SPSS software version 16. Level of signiﬁcance was considered less than 0.05. Results: Seventy patients were studied (male = 56%, average age = 38 15). 25 patients (36.2%) were newly diagnosed. The average period of disease was 4.1 ± 5 years. 25 individuals (35.7%) had mild, 19 individuals (27.1%) had moderate, and 26 individuals (37.1%) had severe disease. Averages of fecal calprotectin in mild, moderate, and severe disease were 132 111, 119 44 and 141 78 g/ g, respectively. Averages of fecal calprotectin in mild and moderate disease (P = 0.874), in mild and severe (P = 0.925) and in moderate and severe disease (P = 0.662) were not signiﬁcantly diﬀerent. Conclusions: Although fecal calprotectin in severe ulcerative colitis is higher, it has no relation with disease clinical activity.