Effect of Amphotericin B on Treatment of Chronic Rhinosinusitis: A Double-blind Randomized Clinical Trial

Authors

1 Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

2 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

3 Department of Otolaryngology, Resident of Otolaryngology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

4 Department of Otolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

5 Students’ Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

10.5812/rijm.64550

Abstract

Abstract Background: Chronic rhinosinusitis (CRS) is the inflammation of paranasal sinusmucousmembranes. Considering the influence of fungi on chronic rhinosinusitis and different results concerning the effect of Amphotericin B on improvement of this condition; this study aimed to determine the effect of topical Amphotericin B on improvement of the symptoms in patients with CRS. Methods: In this double-blind randomized clinical trial, 80 patients with chronic rhinosinusitis who visited the allergy clinic of BaqiyatallahHospital fromJune toOctober 2014were randomly allocated to two groups; the first group received 10 cc topical lavage of Amphotericin B (5 cc each nostril for every 12 hours) and the second group received placebo for threemonths. Symptoms, nasal mucusa smear, serumlevel of inflammatory cytokines, CT scan and rhinoscopy score changes were evaluated in both groups after threemonths. Results: Fifty-five male and 25 female patients were evaluated in two groups. The mean age was 26.1  2.36 and 27.9  1.59 years in intervention and control groups respectively (P = 0.08). There were no significant differences in demographic data between the groups (P > 0.05). Nasal obstruction, post nasal drip (PND), reduced sense of smell, quality of life, CT scan and rhinoscopy scores were not significantly different between the two groups after intervention (P > 0.05). Facial pain severity score was significantly more reduced in intervention group in comparison with control group (P < 0.01). Conclusions: We concluded that application of Amphotericin B as an adjunctive medication to other common treatments, does not seemto be an efficientmethod for improvement of CRS symptoms.

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