Investigation of the Relation Between Hyperglycemia andMorbidity andMortality Rates in Critically Ill Children inMarch 2013 to February 2014


1 Departement of Biology, Faculty of Sciences, Young Researchers and Elite Club, Islamic Azad University,Mashhad Branch,Mashhad, IR Iran

2 Fellowship of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad, IR Iran

3 Department of Nutrition, Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad, IR Iran

4 Neonatal Research Center, School of Medicine,Mashhad University of Medical Sciences,Mashhad, IR Iran



Abstract Background: The purpose of this study is to determine the frequency of hyperglycemia in nondiabetic critically ill children and to investigate its relationship withmechanical ventilation, length of stay andmortality. Methods: In this original retrospective study, data was (were) collected between 2013 and 2014 from the pediatric intensive care unit data base of Sheikh’s Children Hospital inMashhad, Iran (one hundred admitted children). Results: From among 97 subjects, 49 subjects (50.5%) were hospitalized for more than 10 days, and the mean length of stay wa 14 days. The overall mortality rate was 16 subjects (16.5%) and frequency of hyperglycemia was 24 subjects (24.7%). The median fo blood glucose measurements was 100 mg/dl. Seventy three subjects (75.3%) had a mean blood glucose level in the normal range Overall, 18 subjects (18.6%) had at least one blood glucosemeasurement of 180mg/dL or higher. There was a significant association between hyperglycemia and mortality (P < 0.001). Linear regression analysis showed positive correlation between blood glucose level, length of stay and length of ventilation (P  0.001). The maximum serum glucose concentration positively correlated with duration of mechanical ventilation and length of stay (P < 0.001). Conclusions: Our study found thatmaximumserumglucose concentration positively correlatedwith the duration of mechanica ventilation, length of stay, andmortality.